Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 20/20 | 0.63 |
| ▸ | ADORA2B | P29275 | 20/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 20/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 19/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046225 | 0.97 | ADORA2A (0.60) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL4047223 | 0.91 | ADORA2A (0.60) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL4046852 | 0.86 | ADORA2A (0.69) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL14002574 | 0.83 | ADORA2A (0.61) | ADORA2AADORA1 | |
| SCHEMBL4048587 | 0.83 | ADORA2A (0.60) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL4045523 | 0.83 | ADORA3 (0.55) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL4050764 | 0.82 | ADORA2A (0.57) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL4051302 | 0.81 | ADORA3 (0.56) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL4046647 | 0.81 | ADORA2A (0.58) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL4049226 | 0.80 | ADORA2A (1.00) | ADORA2AADORA2BADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392312-B1 | TRIAZOLO 4,5-d PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RES LTD (GB) | 2009-03-04 | — | — | EP | claimed |