Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 2/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6110306 | 0.73 | ALDH1A1 (0.40) | GRNSORT1ALDH1A1GAAKDM4E | |
| SCHEMBL21604161 | 0.71 | SMYD3 (0.35) | GRNSORT1ALDH1A1GAAKDM4E | |
| SCHEMBL3956674 | 0.70 | ALDH1A1 (0.38) | GRNSORT1ALDH1A1GAAKDM4E | |
| SCHEMBL28326595 | 0.69 | ALDH1A1 (0.56) | GRNSORT1ALDH1A1GAAKDM4E | |
| SCHEMBL27258302 | 0.69 | GRN (0.40) | GRNSORT1ALDH1A1GAAKDM4E | |
| SCHEMBL24014224 | 0.68 | CA12 (0.40) | GAAKDM4E | |
| SCHEMBL6379359 | 0.67 | GRN (0.33) | GRNSORT1ALDH1A1GAAKDM4E | |
| SCHEMBL17672402 | 0.66 | KDM4E (0.37) | GRNSORT1ALDH1A1GAAKDM4E | |
| SCHEMBL27258467 | 0.66 | ALDH1A1 (0.37) | GRNSORT1ALDH1A1GAAKDM4E | |
| SCHEMBL2215308 | 0.64 | GRN (0.41) | GRNSORT1ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551403-B1 | 5-SUBSTITUTED 2H-PYRAZONE-3-CARBOXYLIC ACID DERIVATIVES AS ANTILIPOLYTIC AGENTS FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS SUCH AS DYSLIPIDEMIA | ARENA PHARM INC (US) | 2009-04-29 | — | — | EP | disclosed |