Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 15/20 | 0.42 |
| ▸ | LCK | P06239 | 5/20 | 0.42 |
| ▸ | SRC | P12931 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046163 | 0.71 | AURKA (0.41) | MEN1HTTKMT2AHSD17B10SRC | |
| SCHEMBL30353143 | 0.69 | MEN1 (0.51) | MEN1HTTKMT2AHSD17B10SRC | |
| SCHEMBL30353126 | 0.68 | MEN1 (0.50) | MEN1HTTKMT2AHSD17B10SRC | |
| SCHEMBL30353167 | 0.67 | MEN1 (0.56) | MEN1HTTKMT2AHSD17B10RET | |
| SCHEMBL3951464 | 0.67 | IGF1R (0.49) | MEN1HTTKMT2AHSD17B10RET | |
| SCHEMBL18642791 | 0.66 | RET (0.64) | RETLCKSRC | |
| SCHEMBL25472741 | 0.65 | MEN1 (0.54) | MEN1HTTKMT2AHSD17B10SRC | |
| SCHEMBL30353163 | 0.65 | MEN1 (0.47) | MEN1HTTKMT2AHSD17B10RET | |
| SCHEMBL30353135 | 0.65 | MEN1 (0.47) | MEN1HTTKMT2AHSD17B10SRC | |
| SCHEMBL30353127 | 0.65 | MEN1 (0.47) | MEN1HTTKMT2AHSD17B10SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812424-A4 | KINASE INHIBITORS | MIIKANA THERAPEUTICS INC (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-1812424-A2 | KINASE INHIBITORS | Miikana Therapeutics, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006055831-A2 | KINASE INHIBITORS | MIIKANA THERAPEUTICS, INC. (US) | 2006-05-26 | — | — | WO | disclosed |