Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 13/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 6/20 | 0.39 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046155 | 0.71 | MEN1 (0.44) | AURKAAURKBMEN1HTTKMT2A | |
| SCHEMBL12105481 | 0.71 | ITK (0.42) | AURKAAURKBMEN1HTTKMT2A | |
| SCHEMBL1087829 | 0.71 | AURKB (0.71) | AURKAAURKBIGF1RFGFR1KDR | |
| SCHEMBL12105461 | 0.68 | AURKA (0.52) | AURKAAURKBMEN1HTTKMT2A | |
| SCHEMBL4005596 | 0.68 | MEN1 (0.59) | AURKAAURKBMEN1HTTKMT2A | |
| SCHEMBL28423225 | 0.67 | AURKA (0.44) | AURKAAURKBIGF1RFGFR1KDR | |
| SCHEMBL29972030 | 0.66 | CCNA2 (0.58) | MEN1KMT2ASRCCCNA2CDK2 | |
| SCHEMBL4171606 | 0.65 | AURKA (0.44) | AURKAAURKBMEN1HTTKMT2A | |
| SCHEMBL3951464 | 0.65 | IGF1R (0.49) | AURKAAURKBMEN1HTTKMT2A | |
| SCHEMBL14657619 | 0.64 | IGF1R (0.64) | AURKAAURKBIGF1RPAK4PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812424-A4 | KINASE INHIBITORS | MIIKANA THERAPEUTICS INC (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-1812424-A2 | KINASE INHIBITORS | Miikana Therapeutics, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006055831-A2 | KINASE INHIBITORS | MIIKANA THERAPEUTICS, INC. (US) | 2006-05-26 | — | — | WO | disclosed |