Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5483250 | 0.98 | LTA4H (0.38) | LTA4HHRH3HRH2HRH1MAOB | |
| SCHEMBL4052146 | 0.98 | LTA4H (0.38) | LTA4HHRH3HRH2HRH1MAOB | |
| Hydrochloric Acid SCHEMBL2585028 | 0.95 | LTA4H (0.37) | LTA4HHRH3HRH2HRH1MAOB | |
| Hydrochloric Acid SCHEMBL10761360 | 0.95 | LTA4H (0.37) | LTA4HHRH3HRH2HRH1MAOB | |
| Hydrochloric Acid SCHEMBL2968545 | 0.85 | HRH2 (0.31) | HRH3HRH2HRH1 | |
| Hydrochloric Acid SCHEMBL4444394 | 0.85 | HRH2 (0.31) | HRH3HRH2HRH1 | |
| SCHEMBL10370873 | 0.84 | HRH3 (0.43) | LTA4HHRH3HRH2HRH1MAOB | |
| SCHEMBL3275933 | 0.84 | HRH3 (0.43) | LTA4HHRH3HRH2HRH1MAOB | |
| Hydrochloric Acid SCHEMBL11613952 | 0.82 | HRH3 (0.42) | LTA4HHRH3HRH2HRH1MAOB | |
| Hydrochloric Acid SCHEMBL2884926 | 0.82 | HRH3 (0.42) | LTA4HHRH3HRH2HRH1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689720-B1 | PYRAZOLYL DERIVATIVES IN THE FORM OF DRUGS FOR TREATING ACUTE OR CHRONIC NEURONAL REGRESSIONS | AVENTIS PHARMA SA (FR) | 2009-04-15 | — | — | EP | disclosed |
| EP-1689720-A1 | PYRAZOLYL DERIVATIVES IN THE FORM OF DRUGS FOR TREATING ACUTE OR CHRONIC NEURONAL REGRESSIONS | Aventis Pharma S.A. (FR) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005051917-A9 | PYRAZOLYL DERIVATIVES IN THE FORM OF DRUGS FOR TREATING ACUTE OR CHRONIC NEURONAL REGRESSIONS | AVENTIS PHARMA SA (FR) | 2005-09-29 | — | — | WO | disclosed |
| WO-2005051917-A1 | PYRAZOLYL DERIVATIVES IN THE FORM OF DRUGS FOR TREATING ACUTE OR CHRONIC NEURONAL REGRESSIONS | AVENTIS PHARMA S.A. (FR) | 2005-06-09 | — | — | WO | disclosed |