Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.54 |
| ▸ | PDE4A | P27815 | 6/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5245426 | 0.93 | KDM4E (0.61) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL4047111 | 0.92 | KDM4E (0.60) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL4045742 | 0.92 | KDM4E (0.66) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL4044859 | 0.92 | ALDH1A1 (0.74) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL5011421 | 0.83 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL4045649 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL5015893 | 0.83 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL5242293 | 0.81 | KDM4E (0.54) | KDM4EALDH1A1HPGDHIF1ANPSR1 | |
| SCHEMBL4048395 | 0.80 | PDE4B (0.62) | KDM4EALDH1A1PDE4BPDE4APDE4D | |
| SCHEMBL4046040 | 0.78 | HPGD (0.74) | KDM4EALDH1A1HPGDHIF1APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819710-B1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | ALMIRALL LAB (ES) | 2009-03-11 | — | — | EP | disclosed |
| US-20090029955-A1 | Pyridothienopyrimidine Derivatives | ALMIRALL PRODESFARMA S.A. (ES) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029955-A1 | Pyridothienopyrimidine Derivatives | PNPO, PDE4A, DPYD | KDM4E 1600/4885ALDH1A1 391/4885HPGD 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.