Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.56 |
| ▸ | HTR2C | P28335 | 10/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037589 | 0.92 | HTR2A (0.67) | HTR2AHTR2CMAPTEPHX2LMNA | |
| SCHEMBL3945383 | 0.87 | HTR2A (0.58) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4040392 | 0.87 | HTR2A (0.64) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4036853 | 0.87 | MAPT (0.58) | HTR2AHTR2CMAPTKMT2ALMNA | |
| SCHEMBL4035818 | 0.83 | HTR2A (0.61) | HTR2AHTR2CMAPTKCNH2KMT2A | |
| SCHEMBL4040177 | 0.83 | HTR2A (0.66) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4042460 | 0.81 | HTR2A (0.65) | HTR2AHTR2C | |
| SCHEMBL3947503 | 0.81 | HTR2A (0.81) | HTR2AHTR2CLMNA | |
| SCHEMBL4043358 | 0.80 | HTR2A (0.72) | HTR2AHTR2CMAPTKCNH2 | |
| SCHEMBL3949290 | 0.80 | HTR2A (0.67) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051978-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | claimed |
| WO-2007136875-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007136875-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |