Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041725 | 0.89 | CACNA1B (0.41) | CACNA1BCACNA1HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4044268 | 0.87 | CACNA1B (0.45) | CACNA1BCACNA1HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4045987 | 0.84 | HDAC3 (0.41) | CACNA1BCACNA1HKDM4EALDH1A1PDK2 | |
| SCHEMBL4044507 | 0.83 | PDK2 (0.43) | CACNA1BCACNA1HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4049133 | 0.83 | CACNA1B (0.44) | CACNA1BCACNA1HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4043269 | 0.83 | KDM4E (0.44) | CACNA1BCACNA1HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4050340 | 0.83 | CACNA1B (0.42) | CACNA1BCACNA1HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4044883 | 0.81 | CACNA1B (0.43) | CACNA1BCACNA1HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4043584 | 0.81 | PDK2 (0.41) | CACNA1BCACNA1HPDK2MAOBSIGMAR1 | |
| SCHEMBL4044255 | 0.78 | PDK2 (0.43) | CACNA1BCACNA1HKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603921-B1 | THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-17 | — | — | EP | claimed |