Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.53 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL706833 | 0.82 | ALOX5AP (0.72) | ALOX5APCYP4F2CYP4A11ADAMTS4PDE10A | |
| SCHEMBL706834 | 0.82 | ALOX5AP (0.72) | ALOX5APCYP4F2CYP4A11ADAMTS4PDE10A | |
| SCHEMBL708386 | 0.73 | ALOX5AP (0.90) | ALOX5APCYP4F2CYP4A11ADAMTS4MAPT | |
| SCHEMBL708385 | 0.73 | ALOX5AP (0.90) | ALOX5APCYP4F2CYP4A11ADAMTS4MAPT | |
| SCHEMBL710361 | 0.72 | ALOX5AP (0.58) | ALOX5APCYP4F2CYP4A11ADAMTS4MMP13 | |
| SCHEMBL480273 | 0.69 | ALOX5AP (1.00) | ALOX5APADAMTS4MAPT | |
| SCHEMBL707622 | 0.69 | ALOX5AP (0.63) | ALOX5APCYP4F2CYP4A11PDE10AMMP13 | |
| SCHEMBL709308 | 0.69 | ALOX5AP (0.63) | ALOX5APCYP4F2CYP4A11PDE10AMMP13 | |
| SCHEMBL2997218 | 0.68 | ALOX5AP (0.55) | ALOX5APADAMTS4MAPTMMP13PPARD | |
| SCHEMBL2997435 | 0.68 | ALOX5AP (0.86) | ALOX5APADAMTS4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013174-A2 | DIARYL SUBSTITUTED ALKANES | Merck & Co., Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007120574-A2 | DIARYL SUBSTITUTED ALKANES | MERCK & CO., INC. (US) | 2007-10-25 | — | — | WO | disclosed |