Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.72 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL706834 | 1.00 | ALOX5AP (0.72) | ALOX5APCYP4F2CYP4A11PDE10ACYP17A1 | |
| SCHEMBL708386 | 0.90 | ALOX5AP (0.90) | ALOX5APCYP4F2CYP4A11CYP17A1CYP3A4 | |
| SCHEMBL708385 | 0.90 | ALOX5AP (0.90) | ALOX5APCYP4F2CYP4A11CYP17A1CYP3A4 | |
| SCHEMBL710361 | 0.87 | ALOX5AP (0.58) | ALOX5APCYP4F2CYP4A11ADAMTS4 | |
| SCHEMBL709308 | 0.85 | ALOX5AP (0.63) | ALOX5APCYP4F2CYP4A11PDE10A | |
| SCHEMBL707622 | 0.85 | ALOX5AP (0.63) | ALOX5APCYP4F2CYP4A11PDE10A | |
| SCHEMBL480273 | 0.84 | ALOX5AP (1.00) | ALOX5APADAMTS4 | |
| SCHEMBL9924162 | 0.82 | ALOX5AP (0.51) | ALOX5AP | |
| SCHEMBL4046819 | 0.82 | ALOX5AP (0.53) | ALOX5APCYP4F2CYP4A11PDE10AADAMTS4 | |
| SCHEMBL9924121 | 0.82 | ALOX5AP (0.52) | ALOX5APCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124628-B2 | Diaryl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2012-02-28 | — | — | US | claimed |
| US-20090258851-A1 | DIARYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258851-A1 | DIARYL SUBSTITUTED ALKANES | ALOX5, ALOX15, LTB4R2 | ALOX5AP 13/4885CYP4F2 402/4885CYP4A11 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.