Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.48 |
| ▸ | KIT | P10721 | 4/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 4/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041941 | 0.84 | FLT3 (0.69) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4040889 | 0.74 | FLT3 (0.78) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4042930 | 0.73 | FLT3 (0.48) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4037886 | 0.71 | FLT3 (0.52) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4044254 | 0.71 | FLT3 (0.72) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL12845291 | 0.69 | FLT3 (0.66) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4043844 | 0.69 | FLT3 (0.49) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL2088002 | 0.68 | FLT3 (0.79) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL12845289 | 0.68 | FLT3 (0.78) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL14370195 | 0.67 | FLT3 (0.73) | FLT3KITIRAK4AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |