Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL236246 | 1.00 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1MTNR1AMTNR1BPOLB | |
| SCHEMBL3837462 | 0.87 | GRM5 (0.40) | ALDH1A1L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL236125 | 0.87 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL236399 | 0.87 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL236989 | 0.87 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1POLBMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL28053019 | 0.86 | GRM5 (0.39) | ALDH1A1L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL233163 | 0.85 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1MTNR1AMTNR1BPOLB | |
| SCHEMBL234761 | 0.83 | POLB (0.39) | ALDH1A1L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL235310 | 0.83 | POLB (0.39) | ALDH1A1L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL233593 | 0.83 | POLB (0.39) | ALDH1A1L3MBTL1POLBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |