SCHEMBL4047325

SCHEMBL4047325

CC(C)(C)CC(=O)C1C2CNCC2CN1C(=O)O

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.34
CHRNB4 P30926 3/20 0.34
CHRNA3 P32297 3/20 0.34
CHRNA4 P43681 3/20 0.34
CHRNA7 P36544 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18498172 0.75 CHRNB2 (0.45) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL853689 0.74 CHRNB2 (0.38) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
Hydrochloric Acid SCHEMBL19741914 0.73 CHRNB2 (0.37) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL25390583 0.72 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL25388651 0.72 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL12744610 0.70 CHRNB2 (0.37) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
Formic Acid SCHEMBL19971605 0.67 CHRNB2 (0.37) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL2995085 0.66 CHRNB2 (0.48) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL12721645 0.65 CHRNB2 (0.32) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL15100400 0.65 CHRNB2 (0.46) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2086958-A2 SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF Purdue Pharma LP (US) 2009-08-12 EP disclosed
WO-2009027820-A2 SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF PURDUE PHARMA L.P. (DE) 2009-03-05 WO disclosed