Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 16/20 | 0.57 |
| ▸ | BCR | P11274 | 14/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2082746 | 0.87 | MAPK14 (0.78) | BRAFMAPK14ABL1BCRPDGFRA | |
| SCHEMBL2080066 | 0.80 | ABL1 (0.60) | BRAFMAPK14ABL1BCRPDGFRA | |
| SCHEMBL2082457 | 0.80 | BRAF (0.74) | BRAFMAPK14ABL1BCRPDGFRA | |
| SCHEMBL2080644 | 0.78 | BRAF (0.69) | BRAFMAPK14ABL1BCRPDGFRA | |
| SCHEMBL2616946 | 0.76 | MAPK14 (0.61) | BRAFMAPK14 | |
| SCHEMBL2082627 | 0.75 | BRAF (0.78) | BRAFMAPK14ABL1BCRPDGFRA | |
| SCHEMBL4058783 | 0.74 | MAPK14 (0.69) | BRAFMAPK14 | |
| SCHEMBL29366684 | 0.74 | ABL1 (0.83) | BRAFMAPK14ABL1BCRPDGFRA | |
| SCHEMBL28677768 | 0.74 | ABL1 (0.83) | BRAFMAPK14ABL1BCRPDGFRA | |
| SCHEMBL23246300 | 0.72 | ABL1 (0.86) | ABL1BCRPDGFRAKITPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836173-A4 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-07-08 | — | — | EP | claimed |
| EP-1836173-A2 | ANTI-INFLAMMATORY MEDICAMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006081034-A2 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-08-03 | — | — | WO | claimed |