Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 10/20 | 0.42 |
| ▸ | CTSS | P25774 | 5/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15110725 | 0.84 | CA1 (0.49) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL22404434 | 0.83 | CA1 (0.47) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL21794738 | 0.83 | CA2 (0.47) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL14167474 | 0.83 | CA1 (0.47) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL902049 | 0.82 | CA1 (0.58) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL19021911 | 0.82 | CA1 (0.58) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL25231724 | 0.80 | CA1 (0.51) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL13744904 | 0.80 | CA1 (0.51) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL22337395 | 0.80 | CA1 (0.51) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL25278428 | 0.80 | CA1 (0.51) | CA1CA2CA7CYP2D6CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046795-A1 | FURO[3,2-B]PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | Amura Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008007109-A1 | FURO[3,2-B]PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |