Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 7/20 | 0.41 |
| ▸ | CNR2 | P34972 | 6/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.35 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690681 | 1.00 | ROCK1 (0.44) | ROCK1CNR1CNR2GRM4HTR4 | |
| SCHEMBL4053793 | 0.89 | ROCK1 (0.47) | ROCK1CNR1CNR2GRM4HTR4 | |
| SCHEMBL13690641 | 0.89 | ROCK1 (0.47) | ROCK1CNR1CNR2GRM4HTR4 | |
| SCHEMBL13690608 | 0.89 | ROCK1 (0.43) | ROCK1CNR1CNR2GRM4HTR4 | |
| SCHEMBL13690617 | 0.89 | ROCK1 (0.44) | ROCK1CNR1CNR2GRM4HTR4 | |
| SCHEMBL4050830 | 0.89 | ROCK1 (0.44) | ROCK1CNR1CNR2GRM4HTR4 | |
| SCHEMBL4052409 | 0.88 | CNR1 (0.53) | ROCK1CNR1CNR2HTR4CYP3A4 | |
| SCHEMBL4058109 | 0.88 | CNR1 (0.49) | ROCK1CNR1CNR2GRM4HTR4 | |
| SCHEMBL13691270 | 0.88 | ROCK1 (0.46) | ROCK1CNR1CNR2GRM4HTR4 | |
| SCHEMBL13690669 | 0.88 | ROCK1 (0.44) | ROCK1CNR1CNR2GRM4HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |