Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048261 | 1.00 | MEN1 (0.64) | MEN1KMT2AL3MBTL1GRM1MAPK10 | |
| SCHEMBL3420028 | 0.92 | MEN1 (0.61) | MEN1KMT2AL3MBTL1GRM1MAPK10 | |
| SCHEMBL3420023 | 0.92 | MEN1 (0.61) | MEN1KMT2AL3MBTL1GRM1MAPK10 | |
| SCHEMBL3421125 | 0.90 | MEN1 (0.59) | MEN1KMT2AL3MBTL1GRM1MAPK10 | |
| SCHEMBL3421708 | 0.90 | MEN1 (0.59) | MEN1KMT2AL3MBTL1GRM1MAPK10 | |
| SCHEMBL3421711 | 0.90 | MEN1 (0.59) | MEN1KMT2AL3MBTL1GRM1MAPK10 | |
| SCHEMBL3419063 | 0.90 | L3MBTL1 (0.62) | MEN1KMT2AL3MBTL1GRM1ALDH1A1 | |
| SCHEMBL2894215 | 0.90 | MEN1 (0.59) | MEN1KMT2AL3MBTL1GRM1MAPK10 | |
| SCHEMBL3419067 | 0.90 | L3MBTL1 (0.62) | MEN1KMT2AL3MBTL1GRM1ALDH1A1 | |
| SCHEMBL3421121 | 0.90 | MEN1 (0.59) | MEN1KMT2AL3MBTL1GRM1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051983-A1 | NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2009-04-29 | — | — | EP | claimed |
| WO-2008020024-A1 | NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2008-02-21 | — | — | WO | claimed |
| EP-2051983-A1 | NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008020024-A1 | NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2008-02-21 | — | — | WO | disclosed |