Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.51 |
| ▸ | STAT3 | P40763 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767801 | 0.91 | MEN1 (0.59) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4766102 | 0.91 | MEN1 (0.58) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4777490 | 0.90 | MEN1 (0.57) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL2896268 | 0.90 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4775622 | 0.89 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4773187 | 0.87 | MEN1 (0.54) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL13239802 | 0.86 | MEN1 (0.52) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4775702 | 0.86 | MEN1 (0.52) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL2893932 | 0.86 | MEN1 (0.52) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4773298 | 0.85 | MEN1 (0.52) | ALDH1A1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051983-A1 | NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008020024-A1 | NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2008-02-21 | — | — | WO | disclosed |