Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048320 | 0.81 | KDM4E (0.42) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL4223708 | 0.81 | KDM4E (0.43) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL4232401 | 0.78 | TRPV1 (0.42) | PRMT5ALDH1A1GLATRPV1OPRD1 | |
| SCHEMBL1749677 | 0.76 | GSK3A (0.46) | PRMT5ALDH1A1GLAGAATRPV1 | |
| SCHEMBL1749679 | 0.76 | GSK3A (0.46) | PRMT5ALDH1A1GLAGAATRPV1 | |
| SCHEMBL301231 | 0.73 | KDM4E (0.57) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL4050683 | 0.72 | KDM4E (0.43) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL12311356 | 0.70 | OPRD1 (0.53) | KDM4EPRMT5ALDH1A1SMN1; SMN2OPRD1 | |
| SCHEMBL301342 | 0.69 | KDM4E (0.65) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL4237375 | 0.69 | PDE8B (0.43) | PRMT5ALDH1A1SMN1; SMN2TRPV1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |