Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048413 | 0.88 | SLC6A2 (0.35) | MAPTTDP1KMT2AMEN1POLB | |
| SCHEMBL1749675 | 0.75 | MAPT (0.39) | MAPTTDP1GSK3AGSK3BNR1I2 | |
| SCHEMBL4050683 | 0.75 | KDM4E (0.43) | KMT2AMEN1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1749677 | 0.72 | GSK3A (0.46) | MAPTTDP1GSK3AGSK3BNR1I2 | |
| SCHEMBL1749679 | 0.72 | GSK3A (0.46) | MAPTTDP1GSK3AGSK3BNR1I2 | |
| SCHEMBL6121889 | 0.67 | SLC6A3 (0.40) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4436116 | 0.66 | SLC6A4 (0.34) | KMT2AMEN1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL28015927 | 0.65 | GSK3A (0.41) | MAPTTDP1GSK3AGSK3BNR1I2 | |
| SCHEMBL28015937 | 0.65 | GSK3A (0.41) | MAPTTDP1GSK3AGSK3BNR1I2 | |
| SCHEMBL28329578 | 0.64 | SLC6A4 (0.39) | CYP2D6SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |