Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117254 | 0.84 | HDAC3 (0.67) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8069685 | 0.79 | MAPT (0.63) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8069944 | 0.79 | HDAC1 (0.57) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8079292 | 0.77 | HDAC1 (0.53) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4055523 | 0.77 | BCHE (0.56) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29644567 | 0.76 | MAPT (0.55) | MAPTHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL29644577 | 0.75 | HDAC1 (0.55) | MAPTHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL8311235 | 0.75 | HDAC1 (0.53) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5363018 | 0.75 | MAPT (0.60) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5363015 | 0.75 | MAPT (0.60) | MAPTHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026701-A1 | SIRTUIN INHIBITORS | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |