Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.47 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.41 |
| ▸ | CTSK | P43235 | 6/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051572 | 0.92 | TRPV4 (0.64) | TRPV4TAS1R3TAS1R1UTS2RCTSK | |
| SCHEMBL4058972 | 0.92 | TRPV4 (0.56) | TRPV4TAS1R3TAS1R1UTS2RCTSK | |
| SCHEMBL4051481 | 0.92 | TRPV4 (0.64) | TRPV4TAS1R3TAS1R1UTS2RCTSK | |
| SCHEMBL19856860 | 0.92 | TRPV4 (0.64) | TRPV4TAS1R3TAS1R1UTS2RCTSK | |
| SCHEMBL4049334 | 0.92 | TRPV4 (0.64) | TRPV4TAS1R3TAS1R1UTS2RCTSK | |
| SCHEMBL4057834 | 0.91 | TRPV4 (0.56) | TRPV4TAS1R3TAS1R1UTS2RCTSK | |
| SCHEMBL4057534 | 0.91 | TRPV4 (0.55) | TRPV4TAS1R3TAS1R1UTS2RCTSK | |
| SCHEMBL4056988 | 0.91 | TRPV4 (0.55) | TRPV4TAS1R3TAS1R1UTS2RCTSK | |
| SCHEMBL4052494 | 0.89 | TRPV4 (0.42) | TRPV4TAS1R3TAS1R1UTS2RCCR1 | |
| SCHEMBL4059049 | 0.89 | TRPV4 (0.53) | TRPV4TAS1R3TAS1R1UTS2RCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |