Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 8/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | CTSV | O60911 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045688 | 0.99 | DPP4 (0.43) | DPP4DPP7DPP8DPP9CTSK | |
| SCHEMBL4042497 | 0.86 | DPP4 (0.46) | DPP4DPP7DPP8DPP9CTSK | |
| SCHEMBL4047638 | 0.86 | CTSK (0.44) | DPP4DPP7DPP8DPP9CTSK | |
| SCHEMBL4047119 | 0.85 | CTSK (0.52) | DPP4DPP7DPP8DPP9CTSK | |
| SCHEMBL4048576 | 0.85 | DPP4 (0.47) | DPP4DPP7DPP8DPP9CTSK | |
| SCHEMBL4049054 | 0.85 | DPP4 (0.52) | DPP4DPP7DPP8DPP9CTSK | |
| SCHEMBL4050837 | 0.85 | DPP4 (0.44) | DPP4DPP7DPP8DPP9CTSK | |
| SCHEMBL4054797 | 0.84 | CTSK (0.46) | DPP4DPP7DPP8DPP9CTSK | |
| SCHEMBL4048910 | 0.83 | CTSK (0.45) | DPP4DPP7DPP8DPP9CTSK | |
| SCHEMBL4046608 | 0.83 | CTSK (0.45) | DPP4DPP7DPP8DPP9CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |