Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.55 |
| ▸ | SMO | Q99835 | 1/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 3/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | METAP1 | P53582 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | AKT2 | P31751 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583531 | 0.95 | NPY5R (0.54) | NPY5RSMONUDT1PDE5APDE4A | |
| SCHEMBL4111938 | 0.93 | NPY5R (0.57) | NPY5RSMONUDT1PDE5APDE4A | |
| SCHEMBL14447540 | 0.87 | NPY5R (0.53) | NPY5RSMONUDT1PDE5APDE4A | |
| SCHEMBL20284753 | 0.85 | PARP1 (0.56) | NPY5RNUDT1AURKA | |
| SCHEMBL5016405 | 0.79 | AKT1 (0.61) | NPY5RSMOALDH1A1AKT1AKT2 | |
| SCHEMBL19377868 | 0.75 | GRIN2B (0.44) | NPY5RSMOALDH1A1POLBAKT1 | |
| SCHEMBL4059999 | 0.74 | METAP2 (0.38) | NPY5RMETAP1METAP2MAPT | |
| SCHEMBL2674802 | 0.74 | HTR2B (0.55) | NPY5RPOLBMAPT | |
| SCHEMBL31690853 | 0.73 | NPC1 (0.41) | MAPT | |
| SCHEMBL3951535 | 0.73 | NPC1 (0.41) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029625-A1 | 4- [HETEROCYCLYL-METHYL] -8-FLUORO-QUINOLIN-2-ONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |
| WO-2009029625-A1 | 4- [HETEROCYCLYL-METHYL] -8-FLUORO-QUINOLIN-2-ONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |