Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.34 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.34 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31475214 | 1.00 | CYP1A2 (0.39) | CYP1A2HPGDSIRT2ALDH1A1MAPT | |
| SCHEMBL29643977 | 0.91 | SIRT2 (0.40) | CYP1A2HPGDSIRT2ALDH1A1MAPT | |
| SCHEMBL28686145 | 0.91 | SIRT2 (0.40) | CYP1A2HPGDSIRT2ALDH1A1MAPT | |
| SCHEMBL25917375 | 0.86 | CYP1A2 (0.39) | CYP1A2HPGDSIRT2ALDH1A1MAPT | |
| SCHEMBL29183708 | 0.84 | CYP1A2 (0.38) | CYP1A2HPGDSIRT2ALDH1A1MAPT | |
| SCHEMBL30804956 | 0.84 | CYP1A2 (0.38) | CYP1A2HPGDSIRT2ALDH1A1MAPT | |
| SCHEMBL29183716 | 0.83 | CYP1A2 (0.41) | CYP1A2HPGDALDH1A1MAPTRAB9A | |
| SCHEMBL5210462 | 0.83 | CYP1A2 (0.38) | CYP1A2HPGDSIRT2ALDH1A1MAPT | |
| SCHEMBL30804961 | 0.83 | CYP1A2 (0.41) | CYP1A2HPGDALDH1A1MAPTRAB9A | |
| SCHEMBL30387794 | 0.83 | CYP4F2 (0.38) | ALDH1A1DGAT2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109942544-B | Novel indazole derivative kinase inhibitor | 中国科学院合肥物质科学研究院 | 2021-06-11 | — | — | CN | disclosed |
| US-9580406-B2 | Processes for the preparation of axitinib | SIGNA S.A. DE C.V. (MX) | 2017-02-28 | — | — | US | disclosed |
| US-20160318898-A1 | Processes for the Preparation of Axitinib | SIGNA S.A. DE C.V. (MX) | 2016-11-03 | — | — | US | disclosed |
| CN-102134234-B | Indazole urea compound and preparation method and pharmaceutical application thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2013-06-05 | — | — | CN | disclosed |
| CN-102134234-A | Indazole urea compound and preparation method and pharmaceutical application thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2011-07-27 | — | — | CN | disclosed |
| EP-2061772-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | Curis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2009036066-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009036066-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| CN-101094836-A | Methods of making indazole compounds | AGOURON PHARMA (US) | 2007-12-26 | — | — | CN | disclosed |
| CN-101044138-A | Indazole compounds and their use as herbicides | PFIZER (US) | 2007-09-26 | — | — | CN | disclosed |
| EP-1814859-A2 | METHODS FOR PREPARING INDAZOLE COMPOUNDS | Pfizer, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1809625-A1 | METHODS FOR PREPARING INDAZOLE COMPOUNDS | Pfizer, Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006048745-A1 | METHODS FOR PREPARING INDAZOLE COMPOUNDS | PFIZER INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| WO-2006048761-A2 | METHODS FOR PREPARING INDAZOLE COMPOUNDS | PFIZER INC. (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | CYP1A2 4817/4885HPGD 2142/4885SIRT2 168/4885 |
| US-20160318898-A1 | Processes for the Preparation of Axitinib | AURKA, AURKC, AURKB | CYP1A2 1045/4885HPGD 3252/4885SIRT2 3810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.