Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 8/20 | 0.64 |
| ▸ | CNR2 | P34972 | 4/20 | 0.64 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690537 | 1.00 | CNR1 (0.64) | CNR1CNR2HTR4CYP3A4PIK3CD | |
| SCHEMBL30641081 | 0.91 | CNR1 (0.70) | CNR1CNR2CAPN1HTR3AUSP30 | |
| SCHEMBL4050989 | 0.91 | CNR1 (0.70) | CNR1CNR2CAPN1HTR3AUSP30 | |
| SCHEMBL13690923 | 0.91 | CNR1 (0.70) | CNR1CNR2CAPN1HTR3AUSP30 | |
| SCHEMBL4052547 | 0.88 | CNR1 (0.51) | CNR1CNR2HTR4CYP3A4PIK3CD | |
| SCHEMBL13691209 | 0.87 | CNR1 (0.62) | CNR1CNR2HTR4CYP3A4ROCK1 | |
| SCHEMBL13690893 | 0.85 | CNR1 (0.61) | CNR1CNR2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4056691 | 0.85 | CNR1 (0.61) | CNR1CNR2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL13690513 | 0.83 | CNR1 (0.82) | CNR1CNR2HTR4CYP3A4ROCK1 | |
| SCHEMBL4050831 | 0.82 | CNR1 (0.64) | CNR1CNR2HTR4CYP3A4ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |