Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29756954 | 1.00 | MAPT (0.59) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2904660 | 1.00 | MAPT (0.59) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2904656 | 1.00 | MAPT (0.59) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5805555 | 0.83 | TSHR (0.54) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5805553 | 0.83 | TSHR (0.54) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30778025 | 0.83 | TSHR (0.54) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7372200 | 0.81 | TSHR (0.49) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL17548943 | 0.81 | TTR (0.63) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7372197 | 0.81 | TSHR (0.49) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL16881403 | 0.79 | HPGD (0.51) | MAPTGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021117053-A1 | AN IMPROVED PROCESS FOR PREPARATION OF PURE ALDOXIME | DR. SILVIU PHARMACHEM PVT. LTD. (IN) | 2021-06-17 | — | — | WO | claimed |
| CN-116082325-B | Benzoxazinone compound containing isoxazole heterocycle, and preparation method and application thereof | 浙江工业大学 | 2024-04-16 | — | — | CN | disclosed |
| CN-114957123-B | 3- (difluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof | 浙江工业大学 | 2023-11-28 | — | — | CN | disclosed |
| CN-114957124-B | 3- (trifluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof | 浙江工业大学 | 2023-11-07 | — | — | CN | disclosed |
| CN-116082325-A | Benzoxazinone compound containing isoxazole heterocycle, and preparation method and application thereof | 浙江工业大学 | 2023-05-09 | — | — | CN | disclosed |
| CN-114957123-A | 3- (difluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof | 浙江工业大学 | 2022-08-30 | — | — | CN | disclosed |
| CN-114957124-A | 3- (trifluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof | 浙江工业大学 | 2022-08-30 | — | — | CN | disclosed |
| CN-110483332-B | Method for preparing 2, 6-dichlorobenzonitrile by 2, 6-dichlorobenzylamino iodination method | 南京工业大学 | 2022-07-05 | — | — | CN | disclosed |
| CN-109970672-B | Crystal form of high-purity thermostable substituted 3-isoxazolidinone compound, preparation method and application | 浙江省诸暨合力化学对外贸易有限公司 | 2021-07-13 | — | — | CN | disclosed |
| WO-2021117053-A1 | AN IMPROVED PROCESS FOR PREPARATION OF PURE ALDOXIME | DR. SILVIU PHARMACHEM PVT. LTD. (IN) | 2021-06-17 | — | — | WO | disclosed |
| US-7282513-B2 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-16 | — | — | US | disclosed |
| US-20060173054-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2006-08-03 | — | — | US | disclosed |
| WO-2006064484-A1 | AZABICYCLONONENE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-06-22 | — | — | WO | disclosed |
| US-7041689-B2 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME LTD. (GB) | 2006-05-09 | — | — | US | disclosed |
| US-20050182109-A1 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2005-08-18 | — | — | US | disclosed |
| EP-1503998-A1 | HETEROARYL SUBSTITUTED SPIROCYCLIC SUFAMIDES FOR INHIBITION OF GAMMA SECRETASE | MERCK SHARP & DOHME LTD. (GB) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003093252-A1 | HETEROARYL SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR INHIBITION OF GAMMA SECRETASE | MERCK SHARP & DOHME LIMITED (GB) | 2003-11-13 | — | — | WO | disclosed |
| EP-0258391-A1 | USE OF HETEROCYCLIC NITROGEN-CONTAINING COMPOUNDS FOR REDUCING MOISTURE LOSS FROM PLANTS AND INCREASING CROP YIELD | RHONE POULENC NEDERLAND B.V. (NL) | 1988-03-09 | — | — | EP | disclosed |
| WO-1987004321-A2 | USE OF HETEROCYCLIC NITROGEN-CONTAINING COMPOUNDS FOR REDUCING MOISTURE LOSS FROM PLANTS AND INCREASING CROP YIELD | RHONE-POULENC NEDERLANDS B.V. (NL) | 1987-07-30 | — | — | WO | disclosed |
| US-4581365-A | Trichloroacryloyl oxime fungicides | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1986-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182109-A1 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase | BACE1, BACE2, PSEN1 | MAPT 392/4885GRIN2D 234/4885GRIN3B 223/4885 |
| US-20060173054-A1 | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase | BACE1, BACE2, PSEN1 | MAPT 373/4885GRIN2D 158/4885GRIN3B 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.