Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29756954 | 1.00 | MAPT (0.59) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2904660 | 1.00 | MAPT (0.59) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4049047 | 1.00 | MAPT (0.59) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5805555 | 0.83 | TSHR (0.54) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5805553 | 0.83 | TSHR (0.54) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30778025 | 0.83 | TSHR (0.54) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7372200 | 0.81 | TSHR (0.49) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL17548943 | 0.81 | TTR (0.63) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7372197 | 0.81 | TSHR (0.49) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL16881403 | 0.79 | HPGD (0.51) | MAPTGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746448-B1 | NITROGENOUS TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO LTD (CN) | 2025-01-15 | — | — | EP | disclosed |
| US-12162843-B2 | High-purity thermostable crystal form of substituted 3-isoxazolidinone compound, preparation method therefor and application thereof | Zhejiang Zhuji United Chemicals Co., Ltd. (CN) | 2024-12-10 | — | — | US | disclosed |
| US-20220089553-A1 | HIGH-PURITY THERMOSTABLE CRYSTAL FORM OF SUBSTITUTED 3-ISOXAZOLIDINONE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Zhejiang Zhuji United Chemicals Co., Ltd. (CN) | 2022-03-24 | — | — | US | disclosed |
| EP-3971170-A1 | HIGH-PURITY THERMOSTABLE CRYSTAL FORM OF SUBSTITUTED 3-ISOXAZOLIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Zhejiang Zhuji United Chemicals Co., Ltd (CN) | 2022-03-23 | — | — | EP | disclosed |
| US-11208418-B2 | Nitrogenous tricyclic compounds and uses thereof in medicine | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-12-28 | — | — | US | disclosed |
| US-20200392146-A1 | NITROGENOUS TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-12-17 | — | — | US | disclosed |
| US-9580444-B2 | Polycyclic pyrazolinone derivative and herbicide comprising same as effective component thereof | SAGAMI CHEMICAL RESEARCH INSTITUTE (JP) | 2017-02-28 | — | — | US | disclosed |
| US-20160024110-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2016-01-28 | — | — | US | disclosed |
| EP-2975040-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | Sagami Chemical Research Institute (JP) | 2016-01-20 | — | — | EP | disclosed |
| CN-103588679-A | Synthetic method for 2,4-dichlorobenzonitrile | TAICANG YUNTONG BIOCHEMICAL ENGINEERING CO LTD | 2014-02-19 | — | — | CN | disclosed |
| US-7790759-B2 | Glycyrrhetinic acid-30-amide derivatives and their use | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2010-09-07 | — | — | US | disclosed |
| EP-1935892-B1 | GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF | TIANJIN INST PHARM RESEARCH (CN) | 2010-08-11 | — | — | EP | disclosed |
| US-20080214636-A1 | Glycyrrhetinic Acid-30-Amide Derivatives and Their Use | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2008-09-04 | — | — | US | disclosed |
| EP-1935892-A1 | GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2008-06-25 | — | — | EP | disclosed |
| US-4405357-A | Herbicidal 3-isoxazolidinones and hydroxamic acids | FMC CORPORATION (US) | 1983-09-20 | — | — | US | disclosed |
| US-4283403-A | Substituted isoxazolines for control of plant phytopathogens | ELI LILLY AND COMPANY (US) | 1981-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12162843-B2 | High-purity thermostable crystal form of substituted 3-isoxazolidinone compound, preparation method therefor and application thereof | CYP51A1, WEE2, WEE1 | MAPT 4145/4885GRIN2D 2082/4885GRIN3B 3449/4885 |
| US-20160024110-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | DDT, PDHX, CYP4X1 | MAPT 4308/4885GRIN2D 549/4885GRIN3B 919/4885 |
| US-20200392146-A1 | NITROGENOUS TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | NR1H4, SLC10A1, FXR1 | MAPT 148/4885GRIN2D 2474/4885GRIN3B 1183/4885 |
| US-20220089553-A1 | HIGH-PURITY THERMOSTABLE CRYSTAL FORM OF SUBSTITUTED 3-ISOXAZOLIDINONE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | CYP51A1, WEE2, WEE1 | MAPT 4145/4885GRIN2D 2082/4885GRIN3B 3449/4885 |
| US-11208418-B2 | Nitrogenous tricyclic compounds and uses thereof in medicine | NR1H4, SLC10A1, FXR1 | MAPT 148/4885GRIN2D 2474/4885GRIN3B 1183/4885 |
| US-20080214636-A1 | Glycyrrhetinic Acid-30-Amide Derivatives and Their Use | IL36G, CYP26A1, IL17A | MAPT 1573/4885GRIN2D 1738/4885GRIN3B 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.