Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | IL2 | P60568 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12053690 | 0.79 | MAP4K4 (0.48) | MAP4K4MEN1KMT2AHDAC4CYP11B1 | |
| SCHEMBL16321603 | 0.77 | NPC1 (0.44) | MAP4K4MEN1KMT2AIDO1ALDH1A1 | |
| SCHEMBL14237485 | 0.76 | IDO1 (0.48) | MEN1KMT2AIDO1KDM4EPOLB | |
| SCHEMBL14693884 | 0.76 | IDO1 (0.53) | MEN1KMT2AIDO1ALDH1A1MAPT | |
| SCHEMBL4055463 | 0.76 | IDO1 (0.39) | IDO1ALDH1A1MAPTLMNAPKM | |
| SCHEMBL6046592 | 0.73 | IDO1 (0.36) | IDO1LMNAPKMNPC1RAB9A | |
| SCHEMBL16341406 | 0.73 | IDO1 (0.50) | HDAC4IDO1KDM4EALDH1A1MAPT | |
| SCHEMBL4050159 | 0.73 | NPC1 (0.39) | IDO1ALDH1A1MAPTLMNAPKM | |
| SCHEMBL16320974 | 0.73 | IDO1 (0.36) | IDO1ALDH1A1MAPTLMNAPKM | |
| SCHEMBL16340838 | 0.73 | IDO1 (0.40) | IDO1ALDH1A1MAPTLMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879573-A4 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORP (US) | 2009-07-08 | — | — | EP | claimed |
| EP-1879573-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | Incyte Corporation (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006122150-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2006-11-16 | — | — | WO | claimed |