Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3563183 | 0.79 | PDE4B (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4049371 | 0.69 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4049749 | 0.68 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3557228 | 0.66 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3395545 | 0.66 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3559414 | 0.66 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3557146 | 0.66 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3558305 | 0.66 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3557602 | 0.62 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18885945 | 0.60 | HTT (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511072-B2 | 7-amido-isoindolyl compounds and methods of its use | CELGENE CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-20070254942-A1 | 7-amido-isoindolyl compounds and methods of its use | CELGENE CORPORATION. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254942-A1 | 7-amido-isoindolyl compounds and methods of its use | MCL1, THPO, APC | PDE4A 2086/4885PDE4B 1964/4885PDE4C 2369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.