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APC

Adenomatous polyposis coli protein · P25054 · APC on Sugi Atlas →

2,465 patent compounds predicted against APC, 1,319 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2018481 SCHEMBL2018481 0.47 4/20
SCHEMBL2198063 SCHEMBL2198063 0.62 3/20
SCHEMBL1663303 SCHEMBL1663303 0.61 3/20
SCHEMBL1661176 SCHEMBL1661176 0.60 3/20
SCHEMBL1661910 SCHEMBL1661910 0.60 3/20
SCHEMBL2193938 SCHEMBL2193938 0.60 3/20
SCHEMBL10740994 SCHEMBL10740994 0.59 3/20
SCHEMBL10741001 SCHEMBL10741001 0.59 3/20
SCHEMBL10744915 SCHEMBL10744915 0.59 3/20
SCHEMBL10744918 SCHEMBL10744918 0.59 3/20
SCHEMBL11661932 SCHEMBL11661932 0.57 3/20
SCHEMBL11063969 SCHEMBL11063969 0.56 3/20
SCHEMBL2181857 SCHEMBL2181857 0.56 3/20
SCHEMBL1661922 SCHEMBL1661922 0.55 3/20
SCHEMBL1661000 SCHEMBL1661000 0.55 3/20
SCHEMBL1662059 SCHEMBL1662059 0.52 3/20
SCHEMBL1660937 SCHEMBL1660937 0.52 3/20
SCHEMBL9099732 SCHEMBL9099732 0.52 3/20
SCHEMBL9099746 SCHEMBL9099746 0.52 3/20
SCHEMBL2735762 SCHEMBL2735762 0.52 3/20

Clinical trials — most relevant to APC by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA PHASE2/PHASE3COMPLETED
Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride PHASE2/PHASE3COMPLETED
Safety Study for the Use of Rapamycin in Children With Familial Adenomatous Polyposis PHASE2NOT_YET_RECRUITING
The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis PHASE2COMPLETED
Sirolimus and Familial Adenomatous Polyposis (FAP) PHASE2COMPLETED
A Study of Guselkumab in Participants With Familial Adenomatous Polyposis PHASE1COMPLETED
Celecoxib in Preventing Colorectal Cancer in Young Patients With a Genetic Predisposition for Familial Adenomatous Polyposis PHASE1COMPLETED
Molecular Fluorescence Endoscopy in Patients With Familial Adenomatous Polyposis, Using Bevacizumab-IRDye800CW PHASE1COMPLETED
A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy EARLY_PHASE1COMPLETED
Blood and Stool Sample Collection in Subjects Participating in Colorectal Cancer Screening: Act Bold nanCOMPLETED
Exact CRC Screening Test: Stool Sample Collection Study to Support Assay Validation Testing nanCOMPLETED
Esophagogastric Histopathology Potentially Guided Patients Younger Than 50 Years Old to Undergo Colonoscopy Earlier nanUNKNOWN
Microbial and Environmental Factors Associated With Polyps Development in Familial Adenomatous Polyposis (MicrobEnvironment in FAP) nanRECRUITING
Comparative Study of Colon Capsule and Virtual Colonoscopy (VICOCA) nanCOMPLETED
A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome nanCOMPLETED
Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous Polyposis nanUNKNOWN
A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis nanRECRUITING
Establishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform. nanUNKNOWN
A Prospective Study Into the Risk of Colorectal Neoplasms in Individuals With a Family History of Advanced Adenomas (Sibling AN Study) nanUNKNOWN
Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection nanENROLLING_BY_INVITATION
Cold Snare Polypectomy for Duodenal Adenomas in Familial Adenomatous Polyposis nanRECRUITING
Development and Validation of Metabolic Biomarkers for Early Diagnosis, Prognosis, and Recurrence of Gastric Cancer：MetBio-GC nanRECRUITING
Endoscopic Papillectomy for Ampullary Adenomas nanCOMPLETED
Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals nanRECRUITING
Development and Validation of Metabolic Biomarkers for Early Diagnosis, Prognosis, and Recurrence of Colorectal Cancer：MetBio-CRC nanRECRUITING
Colorectal Adenoma Canceration in FAP nanNOT_YET_RECRUITING
Prospective Collection of Samples to Enable the Development of Natera Screening Assay for Early Cancer Detection nanRECRUITING
Non-Surgical Management of Attenuated and Deleterious (Classical) Familial Adenomatous Polyposis: A Long-term Surveillance Program nanCOMPLETED
French Digestive Polyposis Cohorte Family Adenomatous Polyposis With APC and MYH Gene Mutations , Cowden's Disease With PTEN Gene Mutation, Peutz Jeghers Disease With STK 11 Gene Mutation ,juvénil Polyposis With SMAD 4 Gene Mutation , Serrated and Hyperplastic Polyposis nanUNKNOWN
Evaluating the Cologuard Test for Use in Lynch Syndrome nanWITHDRAWN

Related proteins — ESM-2 sequence neighbours (a APC binder may also engage these)

ProteinNameSimilarity
Q61315 — 1.000 Q61315 →
P70478 — 1.000 P70478 →
P70039 — 1.000 P70039 →
A4IIJ3 — 0.995 A4IIJ3 →
Q7Z3E5 — 0.993 Q7Z3E5 →
Q9BXL7 — 0.992 Q9BXL7 →
G5EFD2 — 0.992 G5EFD2 →
Q6DDJ5 — 0.992 Q6DDJ5 →
Q2TLY2 — 0.992 Q2TLY2 →
B3LWS4 — 0.991 B3LWS4 →
Q4V7D3 — 0.991 Q4V7D3 →
Q6NN85 — 0.991 Q6NN85 →
Q6DJR2 — 0.991 Q6DJR2 →
D4AEC2 — 0.991 D4AEC2 →
Q95RG8 — 0.991 Q95RG8 →
Q0VF22 — 0.991 Q0VF22 →
Q17QK1 — 0.991 Q17QK1 →
A9JR78 — 0.991 A9JR78 →
B4PSQ2 — 0.991 B4PSQ2 →
MAP3K13 Mitogen-activated protein kinase kinase kinase 13 0.991 landscape →
Q28161 — 0.991 Q28161 →
Q9VFG8 — 0.991 Q9VFG8 →
B4HEJ6 — 0.991 B4HEJ6 →
Q5ICL9 — 0.991 Q5ICL9 →
O62090 — 0.991 O62090 →
B2GUY1 — 0.991 B2GUY1 →
PTPN13 Tyrosine-protein phosphatase non-receptor type 13 0.991 landscape →
Q8C0T5 — 0.990 Q8C0T5 →
Q9VQ36 — 0.990 Q9VQ36 →
Q5TH69 — 0.990 Q5TH69 →