Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 9/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.56 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.50 |
| ▸ | JAK2 | O60674 | 7/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758775 | 0.96 | MAPK10 (0.60) | MAPK10MAPK8TBK1JAK2MAPK9 | |
| SCHEMBL3756434 | 0.90 | MAPK10 (0.62) | MAPK10MAPK8TBK1JAK2MAPK9 | |
| SCHEMBL3759004 | 0.86 | MAPK10 (0.74) | MAPK10MAPK8TBK1JAK2MAPK9 | |
| SCHEMBL8057480 | 0.85 | MAPK10 (0.59) | MAPK10MAPK8JAK2MAPK9 | |
| SCHEMBL3764854 | 0.85 | MAPK10 (0.61) | MAPK10MAPK8TBK1JAK2MAPK9 | |
| SCHEMBL3753592 | 0.84 | MAPK10 (0.62) | MAPK10MAPK8TBK1JAK2MAPK9 | |
| SCHEMBL3763094 | 0.83 | MAPK10 (0.61) | MAPK10MAPK8TBK1JAK2MAPK9 | |
| SCHEMBL3754746 | 0.82 | MAPK10 (0.59) | MAPK10MAPK8TBK1JAK2MAPK9 | |
| SCHEMBL16404642 | 0.81 | MAPK10 (0.56) | MAPK10MAPK8TBK1JAK2MAPK9 | |
| SCHEMBL3759133 | 0.81 | MAPK10 (0.73) | MAPK10MAPK8TBK1JAK2MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200436-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |