Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.53 |
| ▸ | GPR183 | P32249 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387035 | 0.84 | GPR119 (0.73) | GPR119GPR183KCNH2ATR | |
| SCHEMBL870014 | 0.77 | GPR119 (0.86) | GPR119GPR183KCNH2ATR | |
| SCHEMBL388889 | 0.76 | GPR119 (0.83) | GPR119GPR183KCNH2 | |
| Hydrochloric Acid SCHEMBL387553 | 0.76 | GPR119 (0.84) | GPR119GPR183KCNH2ATR | |
| SCHEMBL1849404 | 0.72 | GPR119 (0.63) | GPR119GPR183 | |
| SCHEMBL387207 | 0.71 | GPR119 (0.66) | GPR119GPR183KCNH2 | |
| SCHEMBL870759 | 0.71 | GPR119 (0.66) | GPR119GPR183KCNH2ATR | |
| SCHEMBL904156 | 0.70 | GPR119 (0.62) | GPR119GPR183KCNH2 | |
| SCHEMBL388819 | 0.70 | GPR119 (0.65) | GPR119GPR183KCNH2 | |
| SCHEMBL387533 | 0.70 | GPR119 (0.65) | GPR119GPR183KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |