Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.49 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.37 |
| ▸ | ACLY | P53396 | 2/20 | 0.36 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856860 | 0.88 | TRPV4 (0.64) | TRPV4CCR1 | |
| SCHEMBL4049334 | 0.88 | TRPV4 (0.64) | TRPV4CCR1 | |
| SCHEMBL4051481 | 0.88 | TRPV4 (0.64) | TRPV4CCR1 | |
| SCHEMBL4051572 | 0.88 | TRPV4 (0.64) | TRPV4CCR1 | |
| SCHEMBL4049305 | 0.85 | TRPV4 (0.42) | TRPV4CCR1HTRA1ALDH1A1LMNA | |
| SCHEMBL4053067 | 0.84 | TRPV4 (0.46) | TRPV4CCR1CASP1HTRA1KMT2A | |
| SCHEMBL4056988 | 0.83 | TRPV4 (0.55) | TRPV4CCR1 | |
| SCHEMBL4058972 | 0.82 | TRPV4 (0.56) | TRPV4CCR1 | |
| SCHEMBL4058975 | 0.82 | TRPV4 (0.56) | TRPV4CCR1 | |
| SCHEMBL4049707 | 0.82 | TRPV4 (0.45) | TRPV4CCR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |