Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16680836 | 0.73 | DYRK1A (0.62) | GRM4DYRK1ATRPA1KDM4ERAB9A | |
| SCHEMBL23695333 | 0.71 | AGBL2 (0.39) | — | |
| SCHEMBL29738172 | 0.71 | AGBL2 (0.39) | — | |
| Bromide SCHEMBL25373037 | 0.70 | AGBL2 (0.38) | — | |
| SCHEMBL25468794 | 0.69 | GRM4 (0.39) | GRM4DYRK1ATRPA1KDM4ERAB9A | |
| SCHEMBL20901588 | 0.69 | GRM4 (0.50) | GRM4TRPA1 | |
| SCHEMBL23500869 | 0.66 | AGBL2 (0.38) | — | |
| SCHEMBL30270583 | 0.66 | AGBL2 (0.38) | — | |
| SCHEMBL30569315 | 0.64 | AGBL2 (0.37) | — | |
| SCHEMBL23530950 | 0.64 | AGBL2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117278-A2 | PROCESSES FOR PREPARING (AMINO-PYRAZOLOPYRIDINYL)METHOXY SUBSTITUTED BIARYL ETHERS | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |