Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | MIF | P14174 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054426 | 0.86 | APP (0.50) | MAPTALDH1A1RAB9AMAPK14SMN1; SMN2 | |
| SCHEMBL14159708 | 0.83 | MAPK14 (0.49) | MAPTALDH1A1RAB9AMAPK14SMN1; SMN2 | |
| SCHEMBL10702618 | 0.83 | MAPK14 (0.55) | MAPTALDH1A1RAB9AMAPK14SMN1; SMN2 | |
| SCHEMBL12121879 | 0.83 | ALDH1A1 (0.46) | MAPTALDH1A1RAB9AMAPK14SMN1; SMN2 | |
| SCHEMBL2197988 | 0.82 | MAPK14 (0.58) | MAPTALDH1A1RAB9AMAPK14SMN1; SMN2 | |
| SCHEMBL4050960 | 0.81 | MAPT (0.63) | MAPTALDH1A1RAB9ASMN1; SMN2APP | |
| SCHEMBL654789 | 0.80 | ALDH1A1 (0.66) | MAPTALDH1A1RAB9AMAPK14SMN1; SMN2 | |
| SCHEMBL11273617 | 0.80 | AKR1B1 (0.55) | MAPK14 | |
| SCHEMBL13765238 | 0.80 | MAPT (0.55) | MAPTALDH1A1RAB9AMAPK14SMN1; SMN2 | |
| SCHEMBL10701723 | 0.79 | MAPT (0.55) | MAPTALDH1A1RAB9AMAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| EP-1560834-B1 | NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS | ALMIRALL LAB (ES) | 2008-06-25 | — | — | EP | disclosed |