Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424777 | 0.86 | ALDH1A1 (0.74) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL4044859 | 0.84 | ALDH1A1 (0.74) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL4049404 | 0.81 | PDE4B (0.70) | KDM4EALDH1A1HPGDPDE4BHSD17B10 | |
| SCHEMBL432053 | 0.81 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL427971 | 0.81 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDHIF1AHSD17B10 | |
| SCHEMBL4053824 | 0.80 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL5015896 | 0.79 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL4045742 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL5011421 | 0.79 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDHIF1APDE4B | |
| SCHEMBL5015893 | 0.78 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDHIF1APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819710-B1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | ALMIRALL LAB (ES) | 2009-03-11 | — | — | EP | disclosed |