Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041749 | 0.92 | CTSK (0.53) | CTSKCTSSHSD17B10HCRTR2LMNA | |
| SCHEMBL4042773 | 0.91 | CTSK (0.55) | CTSKCTSSHSD17B10HCRTR2CCR1 | |
| SCHEMBL4042094 | 0.91 | CTSK (0.53) | CTSKCTSSHSD17B10HCRTR2CCR1 | |
| SCHEMBL4040525 | 0.91 | CTSK (0.53) | CTSKCTSSHSD17B10HCRTR2CCR1 | |
| SCHEMBL4039791 | 0.90 | CTSK (0.64) | CTSKCTSSHSD17B10HCRTR2LMNA | |
| SCHEMBL4037827 | 0.90 | CTSK (0.65) | CTSKCTSSHSD17B10HCRTR2CCR1 | |
| SCHEMBL4043892 | 0.90 | CTSK (0.51) | CTSKCTSSHSD17B10HCRTR2PREP | |
| SCHEMBL4037456 | 0.90 | CTSK (0.51) | CTSKCTSSHSD17B10LMNAPOLB | |
| SCHEMBL4042964 | 0.89 | CTSK (0.49) | CTSKCTSSHSD17B10HCRTR2CTSL | |
| SCHEMBL4039481 | 0.89 | CTSK (0.56) | CTSKCTSSHSD17B10HCRTR2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |