Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.34 |
| ▸ | DRD3 | P35462 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052890 | 0.88 | KDM4E (0.44) | DYRK1AKDM4EALDH1A1SMN1; SMN2PRMT5 | |
| Bromide SCHEMBL7381867 | 0.86 | KDM4E (0.43) | DYRK1AKDM4EALDH1A1SMN1; SMN2PRMT5 | |
| Bromide SCHEMBL7381858 | 0.86 | KDM4E (0.43) | DYRK1AKDM4EALDH1A1SMN1; SMN2PRMT5 | |
| Bromide SCHEMBL10399879 | 0.86 | KDM4E (0.43) | DYRK1AKDM4EALDH1A1SMN1; SMN2PRMT5 | |
| SCHEMBL477109 | 0.84 | DYRK1A (0.53) | DYRK1ACOMTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL23748001 | 0.72 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2AHRPDE10A | |
| SCHEMBL477062 | 0.72 | KDM4E (0.44) | DYRK1AKDM4EALDH1A1SMN1; SMN2PRMT5 | |
| SCHEMBL29020764 | 0.71 | DYRK1A (0.53) | DYRK1ACOMTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3357291 | 0.71 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2AHRDRD2 | |
| SCHEMBL12798307 | 0.71 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079744-A1 | IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008052733-A1 | IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-05-08 | — | — | WO | disclosed |