Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.67 |
| ▸ | TBK1 | Q9UHD2 | 10/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 9/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055513 | 0.86 | AURKA (0.60) | AURKATBK1IKBKEAURKBSMN1; SMN2 | |
| SCHEMBL4054555 | 0.85 | AURKA (0.67) | AURKASMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL4057667 | 0.83 | AURKA (0.60) | AURKASMN1; SMN2 | |
| SCHEMBL4060567 | 0.81 | AURKA (0.68) | AURKASMN1; SMN2NPSR1KDM4ENPC1 | |
| SCHEMBL1667430 | 0.81 | AURKA (0.68) | AURKASMN1; SMN2RXFP1DYRK1BNPC1 | |
| SCHEMBL4056260 | 0.81 | AURKA (0.57) | AURKATBK1SMN1; SMN2LMNAHTT | |
| SCHEMBL4052372 | 0.79 | AURKA (0.69) | AURKATBK1IKBKEAURKBCDK2 | |
| SCHEMBL4054884 | 0.79 | AURKA (0.61) | AURKASMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL4841493 | 0.78 | NPC1 (0.50) | AURKATBK1IKBKEAURKBCDK2 | |
| SCHEMBL16471241 | 0.77 | AURKA (0.63) | AURKASMN1; SMN2HTTNPSR1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-20050101647-A1 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-12 | — | — | US | disclosed |
| EP-1460067-A1 | BICYCLIC DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE | Takeda Chemical Industries, Ltd. (JP) | 2004-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101647-A1 | Bicyclic derivative, its production and use | ABL1, SRC, PTK2B | AURKA 247/4885TBK1 1212/4885IKBKE 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.