Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 16/20 | 0.81 |
| ▸ | USP7 | Q93009 | 10/20 | 0.58 |
| ▸ | USP47 | Q96K76 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1512437 | 0.90 | USP8 (0.71) | USP8USP7USP47NPC1ALDH1A1 | |
| SCHEMBL1512549 | 0.90 | USP8 (1.00) | USP8USP7USP47TP53NPC1 | |
| SCHEMBL4599977 | 0.87 | USP8 (0.62) | USP8USP7USP47TP53 | |
| SCHEMBL4600925 | 0.87 | USP8 (0.83) | USP8USP7USP47TP53 | |
| SCHEMBL4614200 | 0.80 | USP8 (0.61) | USP8USP7USP47 | |
| SCHEMBL4053748 | 0.78 | USP8 (0.58) | USP8USP7USP47 | |
| SCHEMBL4382629 | 0.77 | USP8 (0.72) | USP8USP7USP47TP53 | |
| SCHEMBL1512485 | 0.76 | USP8 (1.00) | USP8USP7USP47NPC1ALDH1A1 | |
| SCHEMBL30931160 | 0.76 | USP8 (1.00) | USP8USP7USP47NPC1ALDH1A1 | |
| SCHEMBL1512579 | 0.76 | USP8 (1.00) | USP8USP7USP47NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009503052-A | — | — | 2009-01-29 | — | — | JP | claimed |
| EP-1912954-A2 | NOVEL CYSTEINE PROTEASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS | Hybrigenics S.A. (FR) | 2008-04-23 | — | — | EP | claimed |
| WO-2007017758-A2 | NOVEL CYSTEINE PROTEASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2007-02-15 | — | — | WO | claimed |