Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 17/20 | 0.83 |
| ▸ | USP7 | Q93009 | 9/20 | 0.51 |
| ▸ | USP47 | Q96K76 | 4/20 | 0.51 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1512579 | 0.91 | USP8 (1.00) | USP8USP7USP47SQOR | |
| SCHEMBL4053539 | 0.87 | USP8 (0.81) | USP8USP7USP47TP53 | |
| SCHEMBL4614200 | 0.86 | USP8 (0.61) | USP8USP7USP47 | |
| SCHEMBL1512437 | 0.84 | USP8 (0.71) | USP8USP7USP47 | |
| SCHEMBL4053748 | 0.83 | USP8 (0.58) | USP8USP7USP47 | |
| SCHEMBL4052507 | 0.79 | USP8 (0.52) | USP8USP7USP47 | |
| SCHEMBL1512549 | 0.77 | USP8 (1.00) | USP8USP7USP47TP53 | |
| SCHEMBL4599977 | 0.76 | USP8 (0.62) | USP8USP7USP47TP53 | |
| SCHEMBL30931160 | 0.71 | USP8 (1.00) | USP8USP7USP47 | |
| SCHEMBL1512485 | 0.71 | USP8 (1.00) | USP8USP7USP47 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912954-A2 | NOVEL CYSTEINE PROTEASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS | Hybrigenics S.A. (FR) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017758-A2 | NOVEL CYSTEINE PROTEASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2007-02-15 | — | — | WO | disclosed |