Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | HTR2C | P28335 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | BCDIN3D | Q7Z5W3 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053566 | 0.93 | KMT2A (0.67) | KMT2AMEN1HTR2CTP53MAPT | |
| SCHEMBL3949781 | 0.91 | HTR2C (0.66) | KMT2AMEN1HTR2CTP53MAPT | |
| SCHEMBL13943692 | 0.90 | KMT2A (0.66) | KMT2AMEN1HTR2CTP53MAPT | |
| SCHEMBL13943251 | 0.88 | HTR2C (0.64) | KMT2AMEN1HTR2CTP53MAPT | |
| SCHEMBL4054590 | 0.88 | BCDIN3D (0.60) | KMT2AMEN1HTR2CTP53MAPT | |
| SCHEMBL13943695 | 0.88 | SYK (0.67) | KMT2AMEN1HTR2CTP53MAPT | |
| SCHEMBL13947360 | 0.86 | TP53 (0.62) | KMT2AMEN1HTR2CTP53MAPT | |
| SCHEMBL13942975 | 0.86 | HTR2C (0.71) | KMT2AHTR2CTP53MAPTKDM4E | |
| SCHEMBL13943694 | 0.86 | SHMT2 (0.68) | KMT2AMEN1HTR2CTP53MAPT | |
| SCHEMBL13943313 | 0.86 | KMT2A (0.68) | KMT2AMEN1TP53MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | claimed |
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |