Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 20/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054031 | 0.87 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4053883 | 0.85 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4059292 | 0.84 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| SCHEMBL4053619 | 0.81 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| SCHEMBL4053529 | 0.81 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4947362 | 0.80 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| SCHEMBL4055129 | 0.80 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4059522 | 0.79 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| SCHEMBL4947338 | 0.78 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4052761 | 0.78 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | claimed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |