Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365639 | 0.94 | TMEM97 (0.49) | MCHR1TMEM97SIGMAR1HTR1AADRA2A | |
| SCHEMBL13748840 | 0.88 | MCHR1 (0.49) | MCHR1TMEM97SIGMAR1HTR1AADRA2A | |
| SCHEMBL4051259 | 0.86 | MCHR1 (0.50) | MCHR1 | |
| SCHEMBL4046428 | 0.85 | MCHR1 (0.49) | MCHR1HRH3 | |
| SCHEMBL4047551 | 0.84 | MCHR1 (0.55) | MCHR1 | |
| SCHEMBL1365799 | 0.81 | HRH3 (0.53) | MCHR1TMEM97SIGMAR1HRH3 | |
| SCHEMBL4045006 | 0.81 | MCHR1 (0.48) | MCHR1ESR2 | |
| SCHEMBL1367079 | 0.81 | MCHR1 (0.48) | MCHR1ESR2 | |
| SCHEMBL4212822 | 0.81 | MCHR1 (0.50) | MCHR1ESR2 | |
| SCHEMBL1367201 | 0.81 | MCHR1 (0.50) | MCHR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |