Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.78 |
| ▸ | MMP13 | P45452 | 1/20 | 0.78 |
| ▸ | MYC | P01106 | 1/20 | 0.71 |
| ▸ | NAT1 | P18440 | 1/20 | 0.71 |
| ▸ | MAX | P61244 | 1/20 | 0.71 |
| ▸ | CTSD | P07339 | 3/20 | 0.70 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 6/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970200 | 1.00 | MMP3 (0.78) | MMP3MMP13MYCNAT1MAX | |
| SCHEMBL4054980 | 1.00 | MMP3 (0.78) | MMP3MMP13MYCNAT1MAX | |
| SCHEMBL4050763 | 0.88 | HPGD (0.82) | MMP3MMP13MYCMAXCTSD | |
| SCHEMBL1250159 | 0.88 | PTPN1 (0.82) | MMP3MMP13NAT1CTSDADAMTS5 | |
| SCHEMBL4051343 | 0.88 | NPC1 (0.79) | MMP3MMP13MYCMAXCTSD | |
| SCHEMBL4056380 | 0.88 | HPGD (0.82) | MMP3MMP13MYCMAXCTSD | |
| SCHEMBL7958282 | 0.88 | MMP3 (0.78) | MMP3MMP13CTSDADAMTS5PTGS2 | |
| SCHEMBL1250155 | 0.88 | PTPN1 (0.82) | MMP3MMP13NAT1CTSDADAMTS5 | |
| SCHEMBL4050762 | 0.88 | HPGD (0.82) | MMP3MMP13MYCMAXCTSD | |
| SCHEMBL7958283 | 0.88 | MMP3 (0.78) | MMP3MMP13CTSDADAMTS5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009109999-A1 | NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS | LUPIN LIMITED (IN) | 2009-09-11 | — | — | WO | disclosed |
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |