Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690841 | 0.87 | KMT2A (0.51) | NPC1GAACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4055759 | 0.87 | ELANE (0.51) | NPC1GAAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL28726087 | 0.80 | HSD17B10 (0.65) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL13691111 | 0.80 | CNR1 (0.70) | NPC1GAAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4050207 | 0.80 | CNR1 (0.70) | NPC1GAAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL6954755 | 0.79 | TSHR (0.52) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL1605879 | 0.78 | TSHR (0.51) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL15881986 | 0.78 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL31429392 | 0.78 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL29805597 | 0.77 | TSHR (0.56) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |