Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608226 | 0.93 | SLC6A2 (0.52) | SLC6A2SLC6A3KCNH2SLC6A4GPR119 | |
| SCHEMBL3600866 | 0.92 | SLC6A2 (0.48) | SLC6A2SLC6A3SLC6A4GPR119KDM4E | |
| SCHEMBL4055778 | 0.91 | GPR119 (0.43) | SLC6A2SLC6A3GPR119KDM4EPKM | |
| SCHEMBL4059631 | 0.87 | SLC6A2 (0.51) | SLC6A2SLC6A3KCNH2SLC6A4GPR119 | |
| SCHEMBL4066284 | 0.87 | GPR119 (0.45) | SLC6A2SLC6A3SLC6A4GPR119KDM4E | |
| SCHEMBL4055719 | 0.86 | SLC6A2 (0.49) | SLC6A2SLC6A3KCNH2SLC6A4GPR119 | |
| SCHEMBL4062683 | 0.84 | GPR119 (0.55) | SLC6A2SLC6A3KCNH2SLC6A4GPR119 | |
| SCHEMBL3608780 | 0.84 | SMN1; SMN2 (0.47) | GPR119KDM4EPKMSMN1; SMN2 | |
| SCHEMBL3600863 | 0.82 | KDM4E (0.46) | GPR119KDM4EPKMSMN1; SMN2 | |
| SCHEMBL4063277 | 0.80 | GPR119 (0.48) | SLC6A2SLC6A4GPR119KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |