Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bromocriptine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.96 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.96 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 9/20 | 1.00 |
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 7/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | USP2 | O75604 | 5/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | STAT6 | P42226 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromocriptine SCHEMBL29893478 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL3393281 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL29360283 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL2405616 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL23468147 | 0.98 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL3134317 | 0.98 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL9526627 | 0.98 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL8032620 | 0.98 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL19276395 | 0.98 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL25297 | 0.98 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9382 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12616693-B2 | Bromocriptine formulations | VEROSCIENCE LLC (US) | 2026-05-05 | — | — | US | claimed |
| US-20260000910-A1 | METHOD FOR TREATING PARKINSON'S DISEASE THROUGH PHOTOSTIMULATION, AND DEVICE USED IN SAID METHOD | TSUBOTA LAB INC (JP) | 2026-01-01 | — | — | US | claimed |
| EP-4342536-B1 | BROMOCRIPTINE FORMULATIONS | VEROSCIENCE LLC (US) | 2025-10-01 | — | — | EP | claimed |
| US-20250275961-A1 | BROMOCRIPTINE FORMULATIONS | VEROSCIENCE LLC | 2025-09-04 | — | — | US | claimed |
| EP-4558622-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | Trailhead Biosystems Inc. (US) | 2025-05-28 | — | — | EP | claimed |
| CN-120051560-A | Methods and compositions for generating human midbrain dopaminergic neurons from neural progenitor cells | 特雷尔赫德生物系统股份有限公司 | 2025-05-27 | — | — | CN | claimed |
| CN-119950440-A | Tablet of dopamine agonist and preparation method thereof | 上海瀚合瑞医药科技有限公司 | 2025-05-09 | — | — | CN | claimed |
| EP-4537896-A1 | METHOD FOR TREATING PARKINSON'S DISEASE THROUGH PHOTOSTIMULATION, AND DEVICE USED IN SAID METHOD | Juntendo Educational Foundation (JP) | 2025-04-16 | — | — | EP | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| CN-119343168-A | Method for treating parkinson's disease by light stimulation and device used in method | 学校法人顺天堂 | 2025-01-21 | — | — | CN | claimed |
| US-5609629-A | Coated implantable medical device | MED INSTITUTE, INC. (US) | 1997-03-11 | — | — | US | claimed |
| CN-1140408-A | Process for preparing solid pharmaceutical dosage forms of hydrophobic substances | SCHERER CORP R P (US) | 1997-01-15 | — | — | CN | claimed |
| EP-0747069-A2 | Implantable medical device | Cook Incorporated (US) | 1996-12-11 | — | — | EP | claimed |
| EP-0737064-A1 | PROCESS FOR PREPARING SOLID PHARMACEUTICAL DOSAGE FORMS OF HYDROPHOBIC SUBSTANCES | R.P. SCHERER CORPORATION (US) | 1996-10-16 | — | — | EP | claimed |
| WO-1996013251-A1 | PROCESS FOR PREPARING SOLID PHARMACEUTICAL DOSAGE FORMS OF HYDROPHOBIC SUBSTANCES | R.P. SCHERER CORPORATION (US) | 1996-05-09 | — | — | WO | claimed |
| EP-0391374-B1 | Processes for the preparation of pharmaceutical compositions containing bromocriptine having high stability and related products | POLI IND CHIMICA SPA (IT) | 1994-12-07 | — | — | EP | claimed |
| EP-0391374-A2 | Processes for the preparation of pharmaceutical compositions containing bromocriptine having high stability and related products | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1990-10-10 | — | — | EP | claimed |
| US-4654345-A | FREE DRYING, VISION DEFECTS, BENZALKONIUM CHLORIDE, POLYMERS, MATRICES, REGENERATION | SANDOZ LTD. (CH) | 1987-03-31 | — | — | US | claimed |
| EP-0207888-A1 | Pharmaceutical tablet | SANDOZ AG (CH) | 1987-01-07 | — | — | EP | claimed |
| US-4366145-A | Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation | SANDOZ, INC. (US) | 1982-12-28 | — | — | US | claimed |