Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 8/20 | 0.53 |
| ▸ | KCNJ5 | P48544 | 8/20 | 0.53 |
| ▸ | KCNJ3 | P48549 | 8/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295138 | 0.85 | MAPK14 (0.59) | KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL4055651 | 0.78 | KCNJ6 (0.56) | KCNJ6KCNJ5KCNJ3EPHX2PTGS2 | |
| SCHEMBL4303828 | 0.76 | MAPK14 (0.66) | MAPK14 | |
| SCHEMBL4050232 | 0.75 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL2083700 | 0.75 | MAPK14 (0.64) | MAPK14 | |
| SCHEMBL4303575 | 0.73 | MAPK14 (0.73) | KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL2082575 | 0.73 | MAPK14 (0.75) | MAPK14 | |
| SCHEMBL4298758 | 0.72 | MAPK14 (0.66) | KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL4297859 | 0.71 | MAPK14 (0.79) | KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL4052031 | 0.69 | KCNJ6 (0.60) | KCNJ6KCNJ5KCNJ3EPHX2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836173-A4 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-1836173-A2 | ANTI-INFLAMMATORY MEDICAMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006081034-A2 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-08-03 | — | — | WO | disclosed |